It is Port Prince at the same time who cradle of Ignacio Agramonte, to prócer of Cuban Independence, the frame for the sprouting of the first épico poem of Cuban Literature.

Writing in 1608 by Wild of Balboa, natural of Canary Islands, the poem reflects a real fact: the kidnapping of a Bishop by a French privateer. It is Mirror of Patience at the same time that expression of the naivete and imagination of the poet, the revelation in blossoming of the mestization that the Cuban would characterize. There they appear, surrounded by the exuberante Cuban nature, náyades in native clothes, fruits and fauna of the Earth next to enslaved Spaniards, Indians and black that constituted the population then. Literature, science and the philosophy had remarkable representatives in this city: Esteban Borrero Echevarría (1849-1906), Gaspar Betancourt Cisneros (1803-1866), Jose de Armas and Ce'spedes (1834-1900), Enrique Jose Varona (1849-1933).

They were, at the same time who founders in the field of Cuban Literature, ancestors of new figures that would give glory to the Cuban culture. Next to Literature they made work of investigation, they emphasized the customs of the region and in many cases they promoted technical advances. A remarkable poetess, Gertrudis Go'mez de Avellaneda (1814-1873) who incursionó also in the theater and the narrative, became outstanding figure of all the Hispanic Literature of speech. To Carlos Juan Finlay, camagüeyano of birth, she must to modern science the discovery of the trasmisor agent of the yellow fever.

In century XX, the camagüeyana culture becomes rich with excellent figures of the Cuban poetry: Nicholas Guillén (1902-1989) and Emilio Ballagas (1908-1954). Considered the National Poet, Nicholas express Guillén with authenticity and artistic quality the problem and essence Cuban of the exploded ones. In its poetry, the rate evokes to are Cuban, whose rythmical scheme is present in the best thing of the pop music of this town.